Hormone Replacement Therapy (HRT)

Hormones are chemical messengers produced by one part of the body to tell cells in another part of the body how to function, when to grow, when to divide, and when to die. They regulate many functions, including growth, sex drive, hunger, thirst, digestion, metabolism, fat burning and storage, blood sugar and cholesterol levels, and reproduction.

The requirements for hormone replacement therapy (HRT) can vary immeasurably. Typically, a certain amount of psychological counseling is required, along with a period of time in the Real Life Experience (RLE) of the desired gender role.

Hormone replacement therapy (HRT) for GRS patients replaces the hormones naturally occurring in their bodies with those of the other sex. However, not all cases GRS patients endure hormone replacement therapy (HRT). It cannot undo the changes produced by the first natural occurring adolescence.

Specifics of bone shape transform throughout life; bones becoming heavier and more deeply sculptured under the influence of testosterone. Changes include:


Pelvis in females tends to be wider than in males and tilted forward; the pelvis in males tends to be more circular and tilted upwards.


Male hands and feet tend to be larger than female hands and feet in persons of equal height.


Females tend to have smaller heads than males of the same height.


Female ribcages tend to be narrower than those of males in the same height.

Facial changes develop gradually over time, and tend to increase with age. Changes include:


Males tend to develop heavier bony brows than females.


Female cheeks tend to be fuller and more rounded. Under the influence of estrogen, fat is deposited beneath the skin and overall facial and body contours become softer.


The tip of the nasal bone tend to grow more in males than females, creating a larger (longer or wider) nose.


The jaw in males tends to grow wider and more deeply sculptured than in females.


At puberty, the bones and cartilage of the voice box tend to enlarge less in females than males. In some males, the larynx becomes perceptible as a bony “Adam’s Apple.”


Females tend to have thicker, fleshier lips than males of the same size.

FTM Hormonal Therapy

For FTMs this can help make the body appear and feel less “feminine” and more “masculine” — making your body more diligently match your identity.

Testosterone is the principal hormone accountable for promoting “male” physical traits, and is usually used for hormonal “masculinization” in FTM patients in Mexico.

Effects of Testosterone Therapy (Cypionate- Depo-Testosterone, Enanthate- Delatestryl):

  • Increased Sex Drive
  • Growth of Clitoris (Typically 1–3 Cm)
  • Increased Growth, Coarseness, and Thickness of Hair
  • Increased Muscle Mass and Upper Body Strength
  • Redistribution of Body Fat to “Masculine” Pattern
  • Menstrual Periods Stop
  • Voice cracks and lowers within three to six months,
  • Gradual Growth of Facial Hair

Risks and Side Effects of HRT

The medications taken in hormone therapy for MTF or FTM patients are managed by the liver; therefore there is a possibility that taking hormones over a long period of time can put strain on the liver, possibly leading to liver disease.

Some FTM testosterone treatments can cause increased irritability, frustration, and anger. Increased fat deposits around internal organs and in the upper abdomen along with higher blood pressure are also risks for FTM patients.




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